BPA “de-masculinizes” male mice: Study
Posted on June 28th, 2011
By Dr Ananya Mandal, MD
Laboratory studies have shown that male mice who are exposed in the womb to bisphenol A, or BPA, a chemical compound found in some hard plastics and can linings, appear to be less masculine and less attractive to females once they mature. This raises controversies that human boys could be similarly affected. The findings were published Monday on the website of the journal Proceedings of the National Academy of Sciences.
In the study male deer mice whose mothers were fed BPA while pregnant had more difficulty navigating a maze and displayed less interest in exploring than unexposed males. This was a sign of “demasculinization,” researchers say, since navigational skill and a propensity for exploration are considered classic male traits in this particular species of mice. What’s more, this reduction in masculinity appears to make BPA-exposed mice less attractive to those potential mates.
In the second part of the experiment female mice who were released into cages containing two male mice, only one of which was exposed to BPA, spent roughly half as much time in “nose-to-nose contact”– an expression of sexual interest – with the BPA-exposed mice, perhaps because the females sensed differences in their behavior, pheromones, or both.
Cheryl Rosenfeld, Ph.D., the lead author of the study and an associate professor of biomedical sciences at the University of Missouri, Columbia said, “The [BPA-exposed] mice outwardly look normal. We have measured their motor skills and done sensory skill assessments, and they look normal; you can’t tell which were exposed. But when you go deeper, that’s when you find this difference emerging. The fact that we found this sexually selected behavior is different.”
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Tags: Male Mice, Mice
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